Journal article
Transforming the Chemical Structure and Bio-Nano Activity of Doxorubicin by Ultrasound for Selective Killing of Cancer Cells
SK Bhangu, S Fernandes, GL Beretta, S Tinelli, M Cassani, A Radziwon, M Wojnilowicz, S Sarpaki, I Pilatis, N Zaffaroni, G Forte, F Caruso, M Ashokkumar, F Cavalieri
Advanced Materials | WILEY-V C H VERLAG GMBH | Published : 2022
Abstract
Reconfiguring the structure and selectivity of existing chemotherapeutics represents an opportunity for developing novel tumor-selective drugs. Here, as a proof-of-concept, the use of high-frequency sound waves is demonstrated to transform the nonselective anthracycline doxorubicin into a tumor selective drug molecule. The transformed drug self-aggregates in water to form ≈200 nm nanodrugs without requiring organic solvents, chemical agents, or surfactants. The nanodrugs preferentially interact with lipid rafts in the mitochondria of cancer cells. The mitochondrial localization of the nanodrugs plays a key role in inducing reactive oxygen species mediated selective death of breast cancer, co..
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Grants
Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
S.K.B. and S.F. contributed equally to this work. This work was supported by the Australian Research Council (ARC) under a Future Fellowship (F.C., FT140100873). F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806). This work received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skodowska-Curie Grant Agreement No. 690901 (NANOSUPREMI). G.F. acknowledges the European Social Fund and European Regional Development Fund-Project MAGNET (Number CZ.02.1.01/0.0/0.0/15_003/0000492). S.K.B. acknowledges the University of Melbourne for support through a Melbourne Research Scholarship and a Norma Hilda Schuster Scholarship. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne. Marco Cassani, an iCARE-2 fellow, has received funding from Fondazione per la Ricerca sul Cancro (AIRC) and the European Union's horizon 2020 research and innovation programme under the Marie Skodowska-Curie Grant Agreement No. 800924. The authors acknowledge Anshul Baral for his assistance with electron microscopy imaging and Helena urikova for helping with the in vitro culture of iPSC-derived cardiomyocytes culture.Open access publishing facilitated by RMIT University, as part of the Wiley - RMIT University agreement via the Council of Australian University Librarians.